本文为《肺移植最新进展(临床)》系列,汇总 2026 年以肺移植为主要主题、发表于 JCR Q1/Q2 区期刊的研究论文(持续更新)。下方按月份逐篇列出:含题目、第一作者与单位、期刊分区与 PMID(可直达 PubMed),并附百字结果/结论导读。全部论文已以 PMID 为索引建库(表 lungtx_papers),便于检索与跟踪。

2026 年 一 月

1Exploring the potential of machine learning in predicting primary graft dysfunction post-lung transplantation.

Q1American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant SurgeonsPMID: 40744427(PubMed)

第一作者:Zehui Liu | 单位:University of Tokyo Hospital, Japan

方法学探讨机器学习预测肺移植后PGD的潜力,指出整合多源临床数据可提升预警能力,呼吁建立标准化数据集与前向验证以推动临床转化。

2Reply to Liu, Zehui-Exploring the potential of machine learning in predicting primary graft dysfunction post-lung transplantation.

Q1American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant SurgeonsPMID: 40818566(PubMed)

第一作者:Inez Oh | 单位:Washington University School of Medicine, USA

作者回应关于机器学习预测肺移植原发性移植物功能障碍(PGD)的讨论,进一步说明模型构建与验证思路,强调该方法在PGD风险预警中的可行性与仍需前瞻验证的局限。

3Probable reactivation from latency of multidrug-resistant cytomegalovirus in a lung transplant recipient: A case report.

Q1American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant SurgeonsPMID: 40850594(PubMed)

第一作者:Julia A Wagner | 单位:University of California, USA

一例CMV血清阴性受者术后缬更昔洛韦3天换莱特莫韦预防3个月,仍于2月后出现MDR-CMV综合征(DNAemia 3.4 log),基因型提示可能来自潜伏期再激活;警示MDR-CMV潜伏再激活风险及现行预防局限。

4Pediatric Lung Waitlist Score (PLWS): A Score to Predict Waitlist Time for Pediatric Lung Transplant Candidates.

Q1Clinical transplantationPMID: 41553123(PubMed)

第一作者:Jose Ramirez | 单位:Baylor College of Medicine, USA

构建儿童肺移植等待者评分(PLWS),纳入青少年、ECMO支持、供区等5项因素,训练集c-statistic 0.71、验证集0.73,可较好预测等待移植时间,辅助儿童供肺分配决策。

2026 年 二 月

5Five-Year Update on Resection of Clustered Pulmonary Arteriovenous Malformations Avoiding Lung Transplantation.

Q1The Annals of thoracic surgeryPMID: 40609669(PubMed)

第一作者:Chika Harada | 单位:University of Tokyo Hospital, Japan

5年随访显示,对 clustered 肺动静脉畸形行局限切除可避免肺移植,中期肺功能与症状改善稳定,为选择性PAVM患者提供器官保留的替代治疗路径。

6Lung transplantation from a 94-year-old donor: A debate on biological versus chronological age.

Q1American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant SurgeonsPMID: 40846150(PubMed)

第一作者:Jan Van Slambrouck | 单位:University Hospitals Leuven, Belgium

报道一例94岁供肺成功用于COPD受者,短期预后良好;端粒长度分析提示其生物学储备保留,支持以生物学年龄而非单纯 chronological age 评估并扩大供体池。

7Regional Variation in Transplant Utilization and Agonal Times among Donation after Circulatory Death Lung Donors in the United States.

Q1Clinical transplantationPMID: 41615308(PubMed)

第一作者:Kentaro Noda | 单位:University of Chicago, USA

美国889例DCD供肺仅部分用于肺移植(其余用于其他器官),DCD肺利用率地区差异显著(低至12%),提示通过优化分配与中心布局可提升DCD肺捐献利用效率。

8Postoperative Atrial Arrhythmias After Lung Transplantation: A Single Center Analysis of Risk Factors, Management, and Outcomes.

Q1Clinical transplantationPMID: 41615334(PubMed)

第一作者:Daniel M Chen | 单位:Feinberg School of Medicine, USA

单中心233例中69例(29.6%)发生术后房性心律失常(POAA),其与校正后死亡风险显著升高(HR 3.09)相关;首次提示POAA即便在出院后仍具临床意义,需加强监测管理。

2026 年 三 月

9From resistance to response: Bacteriophages in multidrug-resistant Mycobacterium abscessus after lung transplantation.

Q1American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant SurgeonsPMID: 41275918(PubMed)

第一作者:Antia Ferreiro-Posse | 单位:Vall d'Hebron University Hospital, Spain

在肺移植后MDR脓肿分枝杆菌感染中,噬菌体治疗伴随CXCL10/IL8等促炎基因上调、免疫逃避通路下调;探索性提示噬菌体或调节宿主免疫并促进细菌清除,值得深入研究。

10Clinical features associated with chronic lung allograft dysfunction progression in a multicenter cohort.

Q1American journal of respiratory and critical care medicinePMID: 41738136(PubMed)

第一作者:Jamie L Todd | 单位:Duke University Medical Center, USA

多中心队列证实,CLAD起病时的常规客观指标可预测其进展风险;这种疾病行为分层有助于受者预后判断,并为未来CLAD临床试验设计提供分层依据。

11Trends and Risk Factors for Suicide in Thoracic Transplantation.

Q1Clinical transplantationPMID: 41772944(PubMed)

第一作者:Emily L Larson | 单位:Johns Hopkins School of Medicine, USA

1995–2022年胸移植受者自杀率109.41/10万,高于一般人群;自杀者多为男性、白人;提示需将心理社会评估与长期精神健康支持纳入移植全程管理。

12Early Trends After Safety Net Policy Introduction for Kidney After Lung Transplantation.

Q1ChestPMID: 41921907(PubMed)

第一作者:Prasanth Balasubramanian | 单位:Mayo Clinic

安全网政策后,肺移植后同期肾移植(SLKT)比例下降、早期KALT上升,肾移植等待时间缩短(94 vs 330天);提示政策改变了肾合并移植的时机与分配格局。

2026 年 四 月

13Lung Transplantation in the Composite Allocation Score Era: Are Older Candidates Disadvantaged?

Q1The Annals of thoracic surgeryPMID: 41962798(PubMed)

第一作者:Shi Nan Feng | 单位:Johns Hopkins University School of Medicine

CAS时代前后共12082名候选者中≥70岁占比上升;Composite Allocation Score未使老年候选者处于劣势,提示新分配框架在年龄公平性上总体可接受。

14Preparing Patients for Life After Lung Transplant: What Can We Tell Them to Expect?

Q1ChestPMID: 41963016(PubMed)

第一作者:David M Sanborn | 单位:William J. von Liebig Center

述评系统梳理肺移植术后长期管理的预期与准备要点,涵盖免疫抑制、感染预防、康复与生活质量,强调以患者为中心的教育可改善依从与远期预后。

15Recent Advances in Lung Transplantation: Innovations Shaping the Next Era.

Q1The Annals of thoracic surgeryPMID: 41985606(PubMed)

第一作者:Keerthana Sankar | 单位:Cedars-Sinai Medical Center

综述指出,供体选择策略提升效率与公平,围术期与术式优化减少并发症、改善早期功能恢复,移植物评估生物标志物与标准化免疫抑制推动肺移植进入新阶段。

16Impact of Invasive Mold Infection-Coded Diagnoses on Utilization, Costs, and Mortality After Lung Transplantation.

Q1ChestPMID: 42061698(PubMed)

第一作者:Kelly M Pennington | 单位:Mayo Clinic

1120例受者中30.6%有侵袭性霉菌感染(IMI)诊断编码(88%为曲霉);男性、囊性纤维化为其独立危险因素,IMI与医疗资源消耗及死亡相关,强调高危人群预防。

2026 年 五 月

17Lung transplantation after prolonged thoraco-abdominal normothermic regional perfusion in combined heart-lung procurement from controlled donation after circulatory death donors in Italy: Can lung graft withstand prolonged thoraco-abdominal normothermic regional perfusion?

Q1American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant SurgeonsPMID: 41581668(PubMed)

第一作者:Vincenzo Verzeletti | 单位:University Hospital of Padua, Italy

意大利24例cDCD供者中16例肺成功用于心肺联合移植,中位功能性热缺血/心停搏时间36/25分钟,证实受控DCD经 prolonged 胸腹常温区域灌注后肺移植物可耐受。

18Uncontrolled donation after circulatory death lung transplantation program: Clinical outcomes and perspectives for implementation.

Q1American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant SurgeonsPMID: 41735096(PubMed)

第一作者:Alessandro Palleschi | 单位:University of Milan, Italy

非控制性DCD(uDCD)肺移植项目30天与1年生存率达94.4%与83.3%,PGD3占16.7%、CLAD 27.8%,证实uDCD供肺临床可行,为扩大供体来源提供实施路径。

19Pre-lung transplant monocyte counts are associated with post-lung transplant survival in idiopathic pulmonary fibrosis.

Q1American journal of respiratory and critical care medicinePMID: 41738233(PubMed)

第一作者:Theodoros Karampitsakos | 单位:Morsani College of Medicine, USA

研究表明,特发性肺纤维化(IPF)受者移植前单核细胞计数与移植后生存相关,为术前免疫状态评估及风险分层、预后改善提供新指标。

20Metabolomic atlas of ischemia-reperfusion injury in human lung transplants: Mitochondrial stress and primary graft dysfunction.

Q1American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant SurgeonsPMID: 42173490(PubMed)

第一作者:Lubiao Liang | 单位:Toronto General Hospital, Canada

人肺移植缺血再灌注代谢组学图谱示PGD3例冷缺血后抗氧化降低、再灌注时牛磺结合胆汁酸升高,谷胱甘肽代谢与PGD相关,提示线粒体应激是PGD核心机制。

2026 年 六 月

21Activation of donor-derived eosinophils during static storage contributes to primary graft dysfunction after lung transplantation.

Q1American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant SurgeonsPMID: 41644052(PubMed)

第一作者:Mojtaba Taheri | 单位:University of Maryland, USA

静态保存中供体来源嗜酸性粒细胞被激活,导致再灌注时氧合下降与组织损伤;低钾右旋糖酐保存液(非其他)诱导其氧化应激,提示优化保存液可减轻PGD。

22Myeloid-avid mammalian target of rapamycin-inhibiting nanobiologic attenuates allograft fibrosis after lung transplantation.

Q1American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant SurgeonsPMID: 42252026(PubMed)

第一作者:Katsutaka Mineura | 单位:Washington University in St. Louis, USA

mTOR抑制纳米生物制剂减少早期巨噬细胞浸润与急性炎症;转录组示肺纤维化基因(巨噬细胞、AT2上皮)下调,提示靶向髓系可减轻肺移植后移植物纤维化。

23OPTN/SRTR 2024 Annual Data Report: Lung.

Q1American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant SurgeonsPMID: 42276701(PubMed)

第一作者:Maryam Valapour | 单位:Hennepin Healthcare Research Institute

2024年报显示肺移植转运距离>500英里者过半,受者1年死亡率9.4%(2023)、5年生存60.1%(2017–2019),早期生存略有改善,供体利用与可及性持续演变。

24Early posttransplant survival after lung transplantation in the Continuous Allocation Era: Associations with changing recipient and donor profiles.

Q1American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant SurgeonsPMID: 42297110(PubMed)

第一作者:Amit Banga | 单位:Stanford Healthcare, USA

持续分配时代早期生存与受者/供者特征变化相关:扩大标准供者、更长转运距离与缺血时间增加;Cox示LAS时代移植与1年死亡独立相关,等待时间不影响。

2026 年 七 月

25Association of follow-up chest computed tomography findings at 6 and 12 weeks with survival in people with invasive pulmonary aspergillosis following lung or allogeneic hematopoietic stem cell transplantation.

Q1American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant SurgeonsPMID: 41724437(PubMed)

第一作者:Roni Bitterman | 单位:Ajmera Transplant Centre, Canada

26Cell type-specific inflammatory response of ischemia-reperfusion injury in lung transplantation.

Q1American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant SurgeonsPMID: 41921751(PubMed)

第一作者:Jinsheng Li | 单位:Toronto General Hospital Research Institute, Canada

27Targeting vascular transient receptor potential vanilloid 4 activity prevents lung transplant ischemia-reperfusion injury and rejection.

Q1American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant SurgeonsPMID: 42419429(PubMed)

第一作者:Fuyi Liao | 单位:Washington University School of Medicine, USA

28CMV Infection after Lung Transplant: incidence, risk factors and management in a multi-center cohort.

Q1American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant SurgeonsPMID: 42486391(PubMed)

第一作者:Laurie D Snyder | 单位:Duke University Medical Center, USA

2026 年 八 月

29The increasing contribution of organ donation after euthanasia to the lung transplantation donor pool in the Netherlands.

Q1American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant SurgeonsPMID: 41997299(PubMed)

第一作者:Nynke Wijbenga | 单位:Department of Respiratory Medicine, Erasmus University Medical Center Rotterdam, Rotterdam, the Netherlands; Erasmus MC Transplant Institute, Erasmus University Medical Center Rotterdam, Rotterdam, the Netherlands.

30Systemic Mitochondrial DNA Kinetics After cDCD Lung Transplantation Do Not Reflect Donor Warm Ischemic Injury: DACMEDAMPs, a Prospective multicenter translational study.

Q1American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant SurgeonsPMID: 42595124(PubMed)

第一作者:Irene Bello | 单位:Thoracic Surgery and Lung Transplant Department. Vall d'Hebron University Hospital, Barcelona, Spain; Organs, tissues and cells donation and transplantation research group. Vall d'hebron Research Institute (VHIR) Barcelona, Spain. Electronic address: Irene.bello@vallhebron.cat.

31Lung Transplant Patient Knowledge of Gastroesophageal Reflux Disease and Foregut Risk Factors Associated With Graft Rejection.

Q1Clinical transplantationPMID: 42616483(PubMed)

第一作者:Annie L Wang | 单位:Duke University School of Medicine, Durham, North Carolina, USA.

32Donor Care Unit Availability and Organ Procurement Organization Performance in Lung Transplantation.

Q1American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant SurgeonsPMID: 42628606(PubMed)

第一作者:Zhizhou Yang | 单位:Division of Cardiothoracic Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, MO; Division of Cardiothoracic Surgery, Department of Surgery, Mass General Brigham, Boston, MA; Department of Biomedical Informatics, Harvard Medical School, Boston, MA. Electronic address: zyang17@mgh.harvard.edu.